Hey everyone so today I wanna discuss a bit about Insulin. Most of this is data was found by Peter Attia. I will try and simplify what I believe you all should know and learn?You may be asking well why this. Well just read further. Tell me that these statistics dont bother you.
- 34% of Americans are obese and two thirds are overweight. This represents more than a 200% increase from 1970.
- Over 8% of Americans are diabetic, and if you include those undiagnosed, an additional 26% of Americans are pre-diabetic. This represents more than a 400% increase from 1970.
- Every 7 seconds someone in the world dies from a diabetic complication (this is not a typo).
Diabetes is also the leading cause of stroke, blindness, kidney failure requiring transplantation, all amputations combined, and many other medical problems.
- According to McKinsey & Company, reducing the U.S. obesity rate to 15% (that of 1970) would save approximately $150 billion per year in Medicare spending alone, and close to $500 billion per year in overall U.S. healthcare spending.
- A recent study in Obesity estimates that by 2030, 50% of Americans will be obese and 79% will be overweight.
Now just because this doesn’t pertain or represent you, you can hopefully learn something and help change another family or friends life for the better.
Insulin – Insulin is a hormone secreted from the pancreas. The cells of the pancreas that secrete insulin are called “beta cells.” Insulin is what we call an “anabolic” hormone, meaning it’s a hormone that helps “build” things (e.g., helps get amino acids into muscle cells, gets glucose into cells). It plays a primary role in how our bodies handle carbohydrates, fats, and proteins – though most people primarily associate insulin only with its role in carbohydrate metabolism.
There is no shortage of stuff to read (e.g., entire textbooks) on insulin, so I won’t even attempt to reproduce it. Let me try to give you the most important info:
Insulin facilitates the delivery of glucose from the bloodstream into cells.
Insulin also up-regulates (i.e., makes more of) an enzyme on the surface of fat cells, called lipoprotein lipase (LPL). LPL, when on fat cells, brings fatty acids into the fat cell to store them at triglycerides. In other words, insulin promotes the storage of fat in fat cells. Similarly, insulin down-regulates (i.e., reduces) LPL on muscle cells. This reduces the ability of muscles to access fatty acids for oxidation (i.e., the prevents muscle cells from burning fat). Very important:
Insulin also promotes the storage of glucose in the liver and muscle as glycogen, provided there is “room” to store them. Both the liver and muscle have a finite, and relatively small, storage capacity for glycogen.
If you remember nothing else, remember this: insulin plays the central role in fat metabolism. When insulin levels are elevated, the body goes into “storage” mode – not just of carbohydrates but also fat. In other words, elevated levels of insulin turn off the ability of the body to burn fat. This is why people are insulin resistant are typically overweight. Insulin resistance (SEE ABOVE CHART) almost always leads to a tonic state of hyperinsulinemia (high insulin), and hence, always storing fat, rather than breaking it down.
If you ever forget this point, just look at the figure below:
High insulin – store fat/don’t break it down
Low insulin – break down fat/don’t store it
Insulin resistance – As the term implies, insulin resistance (IR), involves the tissues of the body (especially muscle cells and fat cells) becoming resistant to the effect of insulin, thereby requiring greater and greater amounts of insulin to achieve the same outcome – namely regulation of glucose in the blood. There is no shortage of discussion and debate about both the cause and mechanism of IR. I enjoy discussing both of these concepts ad nauseam, however, I’ll refrain from doing so here.
Remember this: when you are insulin resistant, you need more insulin to do the same “job.” This is bad for at least two reasons:
Chronically elevated levels of insulin – in and of itself – leads to a non-favorable metabolic state of fat storage over fat oxidation (i.e., storing fat instead of burning it).
In many people, IR leads to diabetes, as the pancreas eventually fails to “keep up” with the demand for insulin. So while insulin levels remain high, blood glucose also remains high. This is called type II diabetes.
If this still goes over your head a bit, which is totally normal, then you can email at firstname.lastname@example.org Remeberthat you control your own destiny. If there is a will then there can be a way. HOW BAD DO YOU WANNA CHANGE????